Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50092656
Substrate
n/a
Meas. Tech.
ChEMBL_54942 (CHEMBL669013)
IC50
120±n/a nM
Citation
Graffner-Nordberg, M; Marelius, J; Ohlsson, S; Persson, A; Swedberg, G; Andersson, P; Andersson, SE; Aqvist, J; Hallberg, A Computational predictions of binding affinities to dihydrofolate reductase: synthesis and biological evaluation of methotrexate analogues. J Med Chem 43:3852-61 (2000) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD