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Target
Tripeptidyl-peptidase 2
Ligand
BDBM50085097
Substrate
n/a
Meas. Tech.
ChEMBL_211948 (CHEMBL816538)
Ki
210000±n/a nM
Citation
 Ganellin, CR; Bishop, PB; Bambal, RB; Chan, SM; Law, JK; Marabout, B; Luthra, PM; Moore, AN; Peschard, O; Bourgeat, P; Rose, C; Vargas, F; Schwartz, JC Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors. J Med Chem 43:664-74 (2000) [PubMed]  Article 
Target
Name:
Tripeptidyl-peptidase 2
Synonyms:
TPP2_RAT | Tpp2 | Tripeptidyl aminopeptidase
Type:
PROTEIN
Mol. Mass.:
138287.08
Organism:
Rattus norvegicus
Description:
ChEMBL_211948
Residue:
1249
Sequence:
MATAATEEPFPFHGLLPKKETGASSFLCRYPEYDGRGVLIAVLDTGVDPGAPGMQVTTDGKPKIIDIIDTTGSGDVNTATEVEPKDGEITGLSGRVLKIPANWTNPSGKYHIGIKNGYDFYPKALKERIQKERKEKIWDPIHRVALAEACRKQEEFDIANNGSSQANKLIKEELQSQVELLNSFEKKYSDPGPVYDCLVWHDGETWRACVDSNENGDLGKSTVLRNYKEAQEYGSFGTAEMLNYSVNIYDDGNLLSIVTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKIGDTRLSTMETGTGLIRAMIEVINHKCDLVNYSYGEATHWPNSGRICEVINEAVWKHNTIYVSSAGNNGPCLSTVGCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRGTQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQGHGIIQVDKAYDYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENSEKISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLFRVPITAVIAAKVNESSHYDLAFTDVHFKPGQIRRHFVEVPEGATWAEVTVCSCSSEVSAKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGTLIEAFPVLGGKAIEFCIARWWASLSDVNIDYTISFHGIVCTAPQLNIHASEGINRFDVQSSLKYEDLAPCITLKSWVQTLRPVNAKTRPLGSRDVLPNNRQLYEMVLTYSFHQPKSGEVTPSCPLLCELLYESEFDSQLWIIFDQNKRQMGSGDAYPHQYSLKLEKGDYTIRLQIRHEQISDLDRLKDLPFIVSHRLSNTLSLDIHENHSLALLGKKKSSSLTLPPKYNQPFFVTSLPDDKIPKGAGPGCYLAGSLTLSKTELGKKADVIPVHYYLIPPPTKTKNGSKDKEKDSEKEKDLKEEFTEALRDLKIQWMTKLDSTDIYNELKETYPAYLPLYVARLHQLDAEKERMKRLNEIVDAANAVISHIDQTALAVYIAMKTDPRPDAATIKNDMDKQKSTLVDALCRKGCALADHLLHAQPHDGAAAGDAEAKEEEGESTLESLSETYWETTKWTDLFDTKVLTFAYKHALVNKMYGRGLKFATKLVEEKPTKENWKNCIQLMKLLGWTHCASFTENWLPIMYPPDYCVF
  
Inhibitor
Name:
BDBM50085097
Synonyms:
2-(2-Amino-3-methyl-butyrylamino)-3-(4-benzyloxy-phenyl)-propionic acid (1.75H2O) | CHEMBL157814
Type:
Small organic molecule
Emp. Form.:
C21H26N2O4
Mol. Mass.:
370.4421
SMILES:
CC(C)C(N)C(=O)NC(Cc1ccc(OCc2ccccc2)cc1)C(O)=O
Structure:
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