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Target
Sodium/glucose cotransporter 1
Ligand
BDBM50422345
Substrate
n/a
Meas. Tech.
ChEMBL_202730 (CHEMBL809058)
Ki
93100±n/a nM
Citation
 Wielert-Badt, S; Lin, JT; Lorenz, M; Fritz, S; Kinne, RK Probing the conformation of the sugar transport inhibitor phlorizin by 2D-NMR, molecular dynamics studies, and pharmacophore analysis. J Med Chem 43:1692-8 (2000) [PubMed]  Article 
Target
Name:
Sodium/glucose cotransporter 1
Synonyms:
High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1
Type:
Protein
Mol. Mass.:
73503.78
Organism:
Homo sapiens (Human)
Description:
P13866
Residue:
664
Sequence:
MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAIPTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVGCTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKGIFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCHAYFA
  
Inhibitor
Name:
BDBM50422345
Synonyms:
CHEMBL2303982
Type:
Small organic molecule
Emp. Form.:
C21H20Br4O10
Mol. Mass.:
751.993
SMILES:
OC[C@@H]1O[C@@H](Oc2c(Br)c(O)c(Br)c(O)c2C(=O)CCc2cc(Br)c(O)c(Br)c2)[C@@H](O)[C@@H](O)[C@@H]1O |r|
Structure:
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