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Target
Histamine H3 receptor
Ligand
BDBM50099622
Substrate
n/a
Meas. Tech.
ChEMBL_86747 (CHEMBL694088)
Ki
0.4±n/a nM
Citation
 De Esch, IJ; Mills, JE; Perkins, TD; Romeo, G; Hoffmann, M; Wieland, K; Leurs, R; Menge, WM; Nederkoorn, PH; Dean, PM; Timmerman, H Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE. J Med Chem 44:1666-74 (2001) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50099622
Synonyms:
1-Cyclohexylmethyl-3-[2-(1H-imidazol-4-yl)-cyclopropyl]-allyl-ammonium
Type:
Small organic molecule
Emp. Form.:
C16H26N3
Mol. Mass.:
260.3972
SMILES:
[NH3+]C(CC1CCCCC1)C=CC1CC1c1cnc[nH]1 |w:9.9|
Structure:
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