Reaction Details Report a problem with these data
Target
Gamma-secretase subunit PEN-2
Ligand
BDBM50100435
Substrate
n/a
Meas. Tech.
ChEMBL_219126 (CHEMBL821806)
IC50
200000±n/a nM
Citation
 Wolfe, MS Secretase targets for Alzheimer's disease: identification and therapeutic potential. J Med Chem 44:2039-60 (2001) [PubMed]  Article 
Target
Name:
Gamma-secretase subunit PEN-2
Synonyms:
Gamma-Secretase Subunit PEN-2 | Gamma-secretase | PEN2 | PEN2_HUMAN | PSENEN | Presenilin enhancer protein 2
Type:
Enzyme subunit; multi-pass membrane protein
Mol. Mass.:
12031.98
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
101
Sequence:
MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP
  
Inhibitor
Name:
BDBM50100435
Synonyms:
CHEMBL305152 | [1-(1-Formyl-butylcarbamoyl)-3-methyl-butyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C19H28N2O4
Mol. Mass.:
348.4366
SMILES:
CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
Structure:
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