Reaction Details Report a problem with these data
Target
Gamma-secretase subunit PEN-2
Ligand
BDBM50369830
Substrate
n/a
Meas. Tech.
ChEMBL_219126 (CHEMBL821806)
IC50
13000±n/a nM
Citation
 Wolfe, MS Secretase targets for Alzheimer's disease: identification and therapeutic potential. J Med Chem 44:2039-60 (2001) [PubMed]  Article 
Target
Name:
Gamma-secretase subunit PEN-2
Synonyms:
Gamma-Secretase Subunit PEN-2 | Gamma-secretase | PEN2 | PEN2_HUMAN | PSENEN | Presenilin enhancer protein 2
Type:
Enzyme subunit; multi-pass membrane protein
Mol. Mass.:
12031.98
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
101
Sequence:
MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLGTP
  
Inhibitor
Name:
BDBM50369830
Synonyms:
CHEMBL1790471
Type:
Small organic molecule
Emp. Form.:
C33H57F2N5O9
Mol. Mass.:
705.8306
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)C(F)(F)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@H](C)CC)C(=O)OC
Structure:
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