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Target
Tyrosine-protein kinase Lck
Ligand
BDBM50101673
Substrate
n/a
Meas. Tech.
ChEMBL_221650 (CHEMBL823227)
Kd
1200±n/a nM
Citation
 Proudfoot, JR; Betageri, R; Cardozo, M; Gilmore, TA; Glynn, S; Hickey, ER; Jakes, S; Kabcenell, A; Kirrane, TM; Tibolla, AK; Lukas, S; Patel, UR; Sharma, R; Yazdanian, M; Moss, N; Beaulieu, PL; Cameron, DR; Ferland, JM; Gauthier, J; Gillard, J; Gorys, V; Poirier, M; Rancourt, J; Wernic, D; Llinas-Brunet, M Nonpeptidic, monocharged, cell permeable ligands for the p56lck SH2 domain. J Med Chem 44:2421-31 (2001) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM50101673
Synonyms:
(RS)2-{4-[2-[1-(4-Methoxy-benzyl)-4-methyl-2-oxo-2,3-dihydro-pyridin-3-ylcarbamoyl]-2-(2-naphthalen-1-yl-acetylamino)-ethyl]-phenyl}-2-methyl-propionic acid | CHEMBL309855
Type:
Small organic molecule
Emp. Form.:
C39H39N3O6
Mol. Mass.:
645.7435
SMILES:
COc1ccc(Cn2ccc(C)c(NC(=O)C(Cc3ccc(cc3)C(C)(C)C(O)=O)NC(=O)Cc3cccc4ccccc34)c2=O)cc1
Structure:
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