Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50106482
Substrate
n/a
Meas. Tech.
ChEMBL_1351 (CHEMBL616536)
Ki
1060±n/a nM
Citation
 Xu, YC; Johnson, KW; Phebus, LA; Cohen, M; Nelson, DL; Schenck, K; Walker, CD; Fritz, JE; Kaldor, SW; LeTourneau, ME; Murff, RE; Zgombick, JM; Calligaro, DO; Audia, JE; Schaus, JM N-[3-(2-Dimethylaminoethyl)-2-methyl-1H- indol-5-yl]-4-fluorobenzamide: a potent, selective, and orally active 5-HT(1F) receptor agonist potentially useful for migraine therapy. J Med Chem 44:4031-4 (2001) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50106482
Synonyms:
CHEMBL339980 | N-[3-(2-Dimethylamino-ethyl)-2-methyl-1H-indol-4-yl]-4-fluoro-benzamide
Type:
Small organic molecule
Emp. Form.:
C20H22FN3O
Mol. Mass.:
339.4066
SMILES:
CN(C)CCc1c(C)[nH]c2cccc(NC(=O)c3ccc(F)cc3)c12
Structure:
Search PDB for entries with ligand similarity: