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Target
Vesicular glutamate transporter 3
Ligand
BDBM50060136
Substrate
n/a
Meas. Tech.
ChEMBL_213566 (CHEMBL816123)
Ki
700000±n/a nM
Citation
 Carrigan, CN; Bartlett, RD; Esslinger, CS; Cybulski, KA; Tongcharoensirikul, P; Bridges, RJ; Thompson, CM Synthesis and in vitro pharmacology of substituted quinoline-2,4-dicarboxylic acids as inhibitors of vesicular glutamate transport. J Med Chem 45:2260-76 (2002) [PubMed]  Article 
Target
Name:
Vesicular glutamate transporter 3
Synonyms:
Slc17a8 | VGLU3_RAT | Vglut3
Type:
PROTEIN
Mol. Mass.:
64750.88
Organism:
Rattus norvegicus
Description:
ChEMBL_213568
Residue:
588
Sequence:
MPFNAFDTFKEKILKPGKEGVKNAVGDSLGILQRKLDGTNEEGDAIELSEEGRPVQTSRARAPVCDCSCCGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWADPENLSEEKCGIIDQDELAEETELNHEAFVSPRKKMSYGATTQNCEVQKTDRRQQRESAFEGEEPLSYQNEEDFSETS
  
Inhibitor
Name:
BDBM50060136
Synonyms:
(1R,3S)-1-Amino-cyclopentane-1,3-dicarboxylic acid | 1-Amino-cyclopentane-1,3-dicarboxylic acid(trans-(1R,3R)-ACPD) | 1-Amino-cyclopentane-1,3-dicarboxylic acid(trans-ACPD) | CHEMBL36988
Type:
Small organic molecule
Emp. Form.:
C7H11NO4
Mol. Mass.:
173.1665
SMILES:
N[C@@]1(CC[C@@H](C1)C(O)=O)C(O)=O
Structure:
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