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Target
Serine protease 1
Ligand
BDBM50066624
Substrate
n/a
Meas. Tech.
ChEMBL_212325 (CHEMBL818251)
Ki
>5000±n/a nM
Citation
 Phillips, G; Guilford, WJ; Buckman, BO; Davey, DD; Eagen, KA; Koovakkat, S; Liang, A; McCarrick, M; Mohan, R; Ng, HP; Pinkerton, M; Subramanyam, B; Ho, E; Trinh, L; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups. J Med Chem 45:2484-93 (2002) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50066624
Synonyms:
3-[6-(3-Carbamimidoyl-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-benzamide | CHEMBL81579
Type:
Small organic molecule
Emp. Form.:
C20H16F2N4O3
Mol. Mass.:
398.3628
SMILES:
Cc1c(F)c(Oc2cccc(c2)C(N)=N)nc(Oc2cccc(c2)C(N)=O)c1F
Structure:
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