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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50115565
Substrate
n/a
Meas. Tech.
ChEMBL_62330 (CHEMBL674269)
Ki
3150±n/a nM
Citation
 Petukhov, PA; Zhang, J; Kozikowski, AP; Wang, CZ; Ye, YP; Johnson, KM; Tella, SR SAR studies of piperidine-based analogues of cocaine. 4. Effect of N-modification and ester replacement. J Med Chem 45:3161-70 (2002) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50115565
Synonyms:
4-(4-Chloro-phenyl)-1-(3-chloro-propyl)-piperidine-3-carboxylic acid methyl ester | CHEMBL325562
Type:
Small organic molecule
Emp. Form.:
C16H21Cl2NO2
Mol. Mass.:
330.249
SMILES:
COC(=O)C1CN(CCCCl)CC[C@@H]1c1ccc(Cl)cc1
Structure:
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