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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50247012
Substrate
n/a
Meas. Tech.
ChEMBL_189 (CHEMBL615225)
IC50
108±n/a nM
Citation
 Barf, T; Vallgårda, J; Emond, R; Häggström, C; Kurz, G; Nygren, A; Larwood, V; Mosialou, E; Axelsson, K; Olsson, R; Engblom, L; Edling, N; Rönquist-Nii, Y; Ohman, B; Alberts, P; Abrahmsén, L Arylsulfonamidothiazoles as a new class of potential antidiabetic drugs. Discovery of potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1. J Med Chem 45:3813-5 (2002) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50247012
Synonyms:
3beta-O-Succinyl-18-beta-glycyrrhetinic acid | Carbenoxolone | US11660306, Example Carbeanoxolone
Type:
Small organic molecule
Emp. Form.:
C34H50O7
Mol. Mass.:
570.7566
SMILES:
CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O)OC(=O)CCC(O)=O |r,t:18|
Structure:
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