Reaction Details Report a problem with these data
Target
P2X purinoceptor 6
Ligand
BDBM50118219
Substrate
n/a
Meas. Tech.
ChEMBL_147418 (CHEMBL750992)
EC50
25000±n/a nM
Citation
 Jacobson, KA; Jarvis, MF; Williams, M Purine and pyrimidine (P2) receptors as drug targets. J Med Chem 45:4057-93 (2002) [PubMed]  Article 
Target
Name:
P2X purinoceptor 6
Synonyms:
ATP receptor | P2RX6 | P2RX6_HUMAN | P2RXL1 | P2X6 | P2XM | Purinergic receptor | Purinergic receptor P2X-like 1
Type:
PROTEIN
Mol. Mass.:
48834.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_612726
Residue:
441
Sequence:
MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPGWPCPSSDTHLPTHSGSL
  
Inhibitor
Name:
BDBM50118219
Synonyms:
Bz-ATP | CHEMBL339386
Type:
Small organic molecule
Emp. Form.:
C23H24N5O14P3
Mol. Mass.:
687.383
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1OC(=O)c1ccc(cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: