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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50120473
Substrate
n/a
Meas. Tech.
ChEMBL_201425 (CHEMBL810658)
Ki
183±n/a nM
Citation
 Maier, CA; Wünsch, B Novel sigma receptor ligands. Part 2. SAR of spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] with carbon substituents in position 3. J Med Chem 45:4923-30 (2002) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50120473
Synonyms:
CHEMBL148236 | ethyl 2-[1'-benzylspiro[3,4-dihydro-1H-isochromene-1,4'-(hexahydropyridine)]-3-yl]acetate
Type:
Small organic molecule
Emp. Form.:
C24H29NO3
Mol. Mass.:
379.492
SMILES:
CCOC(=O)CC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Structure:
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