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Target
Stromelysin-1
Ligand
BDBM50109616
Substrate
n/a
Meas. Tech.
ChEMBL_104748 (CHEMBL715873)
Ki
10.7±n/a nM
Citation
 Sawa, M; Kiyoi, T; Kurokawa, K; Kumihara, H; Yamamoto, M; Miyasaka, T; Ito, Y; Hirayama, R; Inoue, T; Kirii, Y; Nishiwaki, E; Ohmoto, H; Maeda, Y; Ishibushi, E; Inoue, Y; Yoshino, K; Kondo, H New type of metalloproteinase inhibitor: design and synthesis of new phosphonamide-based hydroxamic acids. J Med Chem 45:919-29 (2002) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50109616
Synonyms:
(7-Hydroxycarbamoyl-7,8-dihydro-5H-pyrido[3,4-b]pyrazin-6-yl)-(4-methoxy-phenyl)-phosphinic acid ethyl ester | CHEMBL177072
Type:
Small organic molecule
Emp. Form.:
C17H21N4O5P
Mol. Mass.:
392.3462
SMILES:
CCOP(=O)(N1Cc2nccnc2CC1C(=O)NO)c1ccc(OC)cc1
Structure:
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