Reaction Details Report a problem with these data
Target
Reverse transcriptase/RNaseH
Ligand
BDBM50127515
Substrate
n/a
Meas. Tech.
ChEMBL_195507 (CHEMBL798928)
IC50
9600±n/a nM
Citation
 Hyde, RM; Broom, AD; Buckheit, RW Antiviral amphipathic oligo- and polyribonucleotides: analogue development and biological studies. J Med Chem 46:1878-85 (2003) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50127515
Synonyms:
5-(1-allyl-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-hydroxy-2-(methoxymethyl)tetrahydrofuran-3-yl methylphosphonate
Type:
Small organic molecule
Emp. Form.:
C15H20N4O7P
Mol. Mass.:
399.3162
SMILES:
COC[C@H]1O[C@H](C(O)[C@H]1OP(C)([O-])=O)n1cnc2c1ncn(CC=C)c2=O
Structure:
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