Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50370243
Substrate
n/a
Meas. Tech.
ChEMBL_162193 (CHEMBL766712)
Ki
4.7±n/a nM
Citation
 Evans, GB; Furneaux, RH; Lewandowicz, A; Schramm, VL; Tyler, PC Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase. J Med Chem 46:3412-23 (2003) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50370243
Synonyms:
CHEMBL543164
Type:
Small organic molecule
Emp. Form.:
C12H16N4O4
Mol. Mass.:
280.2798
SMILES:
Cn1cc([C@@H]2N[C@H](CO)[C@H](O)C2O)c2nc[nH]c(=O)c12 |r|
Structure:
Search PDB for entries with ligand similarity: