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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50125886
Substrate
n/a
Meas. Tech.
ChEMBL_72506 (CHEMBL685171)
IC50
22.9±n/a nM
Citation
 Guerlavais, V; Boeglin, D; Mousseaux, D; Oiry, C; Heitz, A; Deghenghi, R; Locatelli, V; Torsello, A; Ghé, C; Catapano, F; Muccioli, G; Galleyrand, JC; Fehrentz, JA; Martinez, J New active series of growth hormone secretagogues. J Med Chem 46:1191-203 (2003) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50125886
Synonyms:
2-Amino-N-{(R)-1-[(R)-1-formylamino-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-1H-indol-3-yl-ethyl}-2-methyl-propionamide | AEZS-130 | ARD-07 | CHEMBL278623 | EP-1572 | JMV-1843 | Macimorelin | Macimorelin acetate | aminoisobutyryl-tryptophyl-tryptophanamine-formyl
Type:
Small organic molecule
Emp. Form.:
C26H30N6O3
Mol. Mass.:
474.5548
SMILES:
CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O
Structure:
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