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Target
Putative alpha-glucosidase
Ligand
BDBM18355
Substrate
n/a
Meas. Tech.
ChEMBL_304920 (CHEMBL827812)
IC50
420±n/a nM
Citation
 Godin, G; Compain, P; Martin, OR; Ikeda, K; Yu, L; Asano, N Alpha-1-C-alkyl-1-deoxynojirimycin derivatives as potent and selective inhibitors of intestinal isomaltase: remarkable effect of the alkyl chain length on glycosidase inhibitory profile. Bioorg Med Chem Lett 14:5991-5 (2004) [PubMed]  Article 
Target
Name:
Putative alpha-glucosidase
Synonyms:
Alpha-glucosidase
Type:
PROTEIN
Mol. Mass.:
102549.55
Organism:
Oryza sativa subsp. japonica
Description:
ChEMBL_304920
Residue:
929
Sequence:
MLASLSSSSRAAISCIPLCLLFLTLASSNGVFAAAPPKVGSGYKLVSLVEHPEGGALVGYLQVKQRTSTYGPDIPLLRLYVKHETKDRIRVQITDADKPRWEVPYNLLQREPAPPVTGGRITGVPFAAGEYPGEELVFTYGRDPFWFAVHRKSSREALFNTSCGALVFKDQYIEASTSLPRDAALYGLGENTQPGGIRLRPNDPYTIYTTDISAINLNTDLYGSHPVYVDLRSRGGHGVAHAVLLLNSNGMDVFYRGTSLTYKVIGGLLDFYLFSGPTPLAVVDQYTSMIGRPAPMPYWAFGFHQCRWGYKNLSVVEGVVEGYRNAQIPLDVIWNDDDHMDAAKDFTLDPVNYPRPKLLEFLDKIHAQGMKYIVLIDPGIAVNNTYGVYQRGMQGDVFIKLDGKPYLAQVWPGPVYFPDFLNPNGVSWWIDEVRRFHDLVPVDGLWIDMNEASNFCTGKCEIPTTHLCPLPNTTTPWVCCLDCKNLTNTRWDEPPYKINASGQTARLGFNTIATSATHYNGILEYNAHSLYGFSQAIATHQALQGLQGKRPFILTRSTFVGSGAYAAHWTGDNKGTWENLRYSISTMLNFGIFGMPMVGADICGFYPQPTEELCNRWIELGAFYPFSRDHANFASPRQELYVWESVAKSARNALGMRYRLLPYLYTLNYQAHLTGAPVARPVFFSFPDFTPCYGLSTQYLLGASVMVSPVLEQGATSVSAMFPPGSWYNLFDTTKVVVSRGEGAVKLDAPLNEINVHVFQNTILPMQRGGTISKEARATPFTLVVAFPFGATEAEAEGAVYVDDDERPEMVLAEGQATYVRFYATVRGKAVTVRSEVELGSYSLQKGLLIEKLSVLGLEGTGRDLAVHVDGANATAIATSRPYFAGAEAELHGHRDVEGHKKSVMVEVGGLALPLGKSFTMTWNMQIEA
  
Inhibitor
Name:
BDBM18355
Synonyms:
(2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol | CHEMBL1029 | MIGLUSTAT | N-Butyl-DNJ | US20230339856, Compound NB-DNJ | US9181184, 5
Type:
Small organic molecule
Emp. Form.:
C10H21NO4
Mol. Mass.:
219.278
SMILES:
CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Structure:
Search PDB for entries with ligand similarity: