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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50167463
Substrate
n/a
Meas. Tech.
ChEMBL_303377 (CHEMBL839695)
Ki
1700±n/a nM
Citation
 Coe, JW; Vetelino, MG; Bashore, CG; Wirtz, MC; Brooks, PR; Arnold, EP; Lebel, LA; Fox, CB; Sands, SB; Davis, TI; Schulz, DW; Rollema, H; Tingley, FD; O'Neill, BT In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine. Bioorg Med Chem Lett 15:2974-9 (2005) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50167463
Synonyms:
5-Difluoromethoxy-11-aza-tricyclo[7.3.1.0*2,7*]trideca-2,4,6-triene | CHEMBL189968
Type:
Small organic molecule
Emp. Form.:
C13H15F2NO
Mol. Mass.:
239.2611
SMILES:
FC(F)Oc1ccc2C3CNCC(C3)Cc2c1
Structure:
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