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Target
Adenosine receptor A3
Ligand
BDBM50166741
Substrate
n/a
Meas. Tech.
ChEMBL_303757 (CHEMBL829800)
Ki
134±n/a nM
Citation
 Press, NJ; Taylor, RJ; Fullerton, JD; Tranter, P; McCarthy, C; Keller, TH; Brown, L; Cheung, R; Christie, J; Haberthuer, S; Hatto, JD; Keenan, M; Mercer, MK; Press, NE; Sahri, H; Tuffnell, AR; Tweed, M; Fozard, JR A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential. Bioorg Med Chem Lett 15:3081-5 (2005) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50166741
Synonyms:
4-(3-cyanophenyl)-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazol-2-ylcarbamate
Type:
Small organic molecule
Emp. Form.:
C13H7N6O2S
Mol. Mass.:
311.299
SMILES:
[O-]C(=O)Nc1nc(c(s1)-n1cncn1)-c1cccc(c1)C#N
Structure:
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