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Target
MO15-related protein kinase Pfmrk
Ligand
BDBM50132005
Substrate
n/a
Meas. Tech.
ChEMBL_306159 (CHEMBL832347)
IC50
17100±n/a nM
Citation
 Bhattacharjee, AK; Geyer, JA; Woodard, CL; Kathcart, AK; Nichols, DA; Prigge, ST; Li, Z; Mott, BT; Waters, NC A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. J Med Chem 47:5418-26 (2004) [PubMed]  Article 
Target
Name:
MO15-related protein kinase Pfmrk
Synonyms:
Protein kinase Pfmrk
Type:
PROTEIN
Mol. Mass.:
37992.30
Organism:
Plasmodium falciparum
Description:
ChEMBL_640752
Residue:
324
Sequence:
MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLLREIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQILNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLNLTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFLLGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAEDAMKHRYFFNDPLPCDISQLPFNDL
  
Inhibitor
Name:
BDBM50132005
Synonyms:
5-Methoxy-3-(4-oxo-2-thioxo-thiazolidin-5-ylidene)-1,3-dihydro-indol-2-one | 5-methoxy-3-(4-oxo-2-thioxothiazolidin-5-ylidene)indolin-2-one | CHEMBL130414 | CHEMBL362785
Type:
Small organic molecule
Emp. Form.:
C12H8N2O3S2
Mol. Mass.:
292.334
SMILES:
COc1ccc2NC(=O)C(=C3SC(S)=NC3=O)c2c1 |w:10.15,c:13|
Structure:
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