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Target
MO15-related protein kinase Pfmrk
Ligand
BDBM50154601
Substrate
n/a
Meas. Tech.
ChEMBL_306159 (CHEMBL832347)
IC50
70000±n/a nM
Citation
 Bhattacharjee, AK; Geyer, JA; Woodard, CL; Kathcart, AK; Nichols, DA; Prigge, ST; Li, Z; Mott, BT; Waters, NC A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. J Med Chem 47:5418-26 (2004) [PubMed]  Article 
Target
Name:
MO15-related protein kinase Pfmrk
Synonyms:
Protein kinase Pfmrk
Type:
PROTEIN
Mol. Mass.:
37992.30
Organism:
Plasmodium falciparum
Description:
ChEMBL_640752
Residue:
324
Sequence:
MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLLREIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQILNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLNLTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFLLGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAEDAMKHRYFFNDPLPCDISQLPFNDL
  
Inhibitor
Name:
BDBM50154601
Synonyms:
(3-Oxo-1-phenyl-1,3-dihydro-isobenzofuran-1-yl)-thiourea | CHEMBL363972
Type:
Small organic molecule
Emp. Form.:
C15H12N2O2S
Mol. Mass.:
284.333
SMILES:
NC(=S)NC1(OC(=O)c2ccccc12)c1ccccc1
Structure:
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