Reaction Details Report a problem with these data
Target
MO15-related protein kinase Pfmrk
Ligand
BDBM50154605
Substrate
n/a
Meas. Tech.
ChEMBL_306159 (CHEMBL832347)
IC50
14000±n/a nM
Citation
 Bhattacharjee, AK; Geyer, JA; Woodard, CL; Kathcart, AK; Nichols, DA; Prigge, ST; Li, Z; Mott, BT; Waters, NC A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors. J Med Chem 47:5418-26 (2004) [PubMed]  Article 
Target
Name:
MO15-related protein kinase Pfmrk
Synonyms:
Protein kinase Pfmrk
Type:
PROTEIN
Mol. Mass.:
37992.30
Organism:
Plasmodium falciparum
Description:
ChEMBL_640752
Residue:
324
Sequence:
MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLLREIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQILNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLNLTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFLLGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAEDAMKHRYFFNDPLPCDISQLPFNDL
  
Inhibitor
Name:
BDBM50154605
Synonyms:
(4-Chloro-phenyl)-[3-(4-chloro-phenyl)-2,4-dioxo-oxazolidin-(5Z)-ylidene]-acetonitrile | CHEMBL363514
Type:
Small organic molecule
Emp. Form.:
C17H8Cl2N2O3
Mol. Mass.:
359.163
SMILES:
Clc1ccc(cc1)N1C(=O)O\C(=C(/C#N)c2ccc(Cl)cc2)C1=O
Structure:
Search PDB for entries with ligand similarity: