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Target
Tubulin beta-1 chain
Ligand
BDBM50168443
Substrate
n/a
Meas. Tech.
ChEMBL_305173 (CHEMBL832762)
IC50
2600±n/a nM
Citation
 Pettit, GR; Rhodes, MR; Herald, DL; Hamel, E; Schmidt, JM; Pettit, RK Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. J Med Chem 48:4087-99 (2005) [PubMed]  Article 
Target
Name:
Tubulin beta-1 chain
Synonyms:
TBB1_HUMAN | TUBB1
Type:
PROTEIN
Mol. Mass.:
50311.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305173
Residue:
451
Sequence:
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
  
Inhibitor
Name:
BDBM50168443
Synonyms:
(Z)-1-(3',4',5'-trimethoxyphenyl)-2-(3''-nitro-4''-methoxyphenyl)ethane | (Z)-5-(4-methoxy-3-nitrostyryl)-1,2,3-trimethoxybenzene | 1,2,3-Trimethoxy-5-[(Z)-2-(4-methoxy-3-nitro-phenyl)-vinyl]-benzene | CHEMBL192224 | ST-3098
Type:
Small organic molecule
Emp. Form.:
C18H19NO6
Mol. Mass.:
345.3466
SMILES:
COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: