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Target
Tubulin beta-1 chain
Ligand
BDBM50168447
Substrate
n/a
Meas. Tech.
ChEMBL_305173 (CHEMBL832762)
IC50
7600±n/a nM
Citation
 Pettit, GR; Rhodes, MR; Herald, DL; Hamel, E; Schmidt, JM; Pettit, RK Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. J Med Chem 48:4087-99 (2005) [PubMed]  Article 
Target
Name:
Tubulin beta-1 chain
Synonyms:
TBB1_HUMAN | TUBB1
Type:
PROTEIN
Mol. Mass.:
50311.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305173
Residue:
451
Sequence:
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
  
Inhibitor
Name:
BDBM50168447
Synonyms:
1-(2-{2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenoxy}-ethyl)-1H-imidazole; hydrochloride | CHEMBL540358
Type:
Small organic molecule
Emp. Form.:
C23H26N2O5
Mol. Mass.:
410.4629
SMILES:
COc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)cc1OCCn1ccnc1
Structure:
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