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Target
Glutamine synthetase
Ligand
BDBM50174521
Substrate
n/a
Meas. Tech.
ChEMBL_321474 (CHEMBL880415)
pH
7.4±n/a
IC50
31000±n/a nM
Comments
extracted
Citation
 Berlicki, L; Obojska, A; Forlani, G; Kafarski, P Design, synthesis, and activity of analogues of phosphinothricin as inhibitors of glutamine synthetase. J Med Chem 48:6340-9 (2005) [PubMed]  Article 
Target
Name:
Glutamine synthetase
Synonyms:
GLN1B_ECOLI | glnA
Type:
PROTEIN
Mol. Mass.:
51891.08
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_321474
Residue:
469
Sequence:
MSAEHVLTMLNEHEVKFVDLRFTDTKGKEQHVTIPAHQVNAEFFEEGKMFDGSSIGGWKGINESDMVLMPDASTAVIDPFFADSTLIIRCDILEPGTLQGYDRDPRSIAKRAEDYLRSTGIADTVLFGPEPEFFLFDDIRFGSSISGSHVAIDDIEGAWNSSTQYEGGNKGHRPAVKGGYFPVPPVDSAQDIRSEMCLVMEQMGLVVEAHHHEVATAGQNEVATRFNTMTKKADEIQIYKYVVHNVAHRFGKTATFMPKPMFGDNGSGMHCHMSLSKNGVNLFAGDKYAGLSEQALYYIGGVIKHAKAINALANPTTNSYKRLVPGYEAPVMLAYSARNRSASIRIPVVSSPKARRIEVRFPDPAANPYLCFAALLMAGLDGIKNKIHPGEAMDKNLYDLPPEEAKEIPQVAGSLEEALNELDLDREFLKAGGVFTDEAIDAYIALRREEDDRVRMTPHPVEFELYYSV
  
Inhibitor
Name:
BDBM50174521
Synonyms:
(S)-2-Amino-4-[((S)-1-amino-ethyl)-hydroxy-phosphinoyl]-butyric acid; hydrochloride | CHEMBL539335 | CHEMBL557574
Type:
Small organic molecule
Emp. Form.:
C6H15N2O4P
Mol. Mass.:
210.1681
SMILES:
CC(=N)P(O)(O)CC[C@H](N)C(O)=O
Structure:
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