Reaction Details
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Guanine nucleotide-binding protein G(i) subunit alpha-1
Ligand
BDBM50174660
Substrate
n/a
Meas. Tech.
ChEMBL_321104 (CHEMBL882870)
EC50
18400±n/a nM
Citation
Manetti, D; Di Cesare Mannelli, L; Dei, S; Galeotti, N; Ghelardini, C; Romanelli, MN; Scapecchi, S; Teodori, E; Pacini, A; Bartolini, A; Gualtieri, F Design, synthesis, and preliminary pharmacological evaluation of a set of small molecules that directly activate gi proteins. J Med Chem 48:6491-503 (2005) [PubMed] Article More Info.:
Target
Name:
Guanine nucleotide-binding protein G(i) subunit alpha-1
Synonyms:
GNAI1 | GNAI1_HUMAN | Guanine nucleotide-binding protein G(i), alpha-1 subunit
Type:
PROTEIN
Mol. Mass.:
40357.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321104
Residue:
354
Sequence:
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Inhibitor
Name:
BDBM50174660
Synonyms:
1-(2-Amino-ethyl)-piperidine-4-carboxylic acid pentadecylamide; dihydrochloride | CHEMBL537856
Type:
Small organic molecule
Emp. Form.:
C23H47N3O
Mol. Mass.:
381.6388
SMILES:
CCCCCCCCCCCCCCCNC(=O)C1CCN(CCN)CC1
Structure:
