Reaction Details Report a problem with these data
Target
Guanine nucleotide-binding protein G(i) subunit alpha-3
Ligand
BDBM50174670
Substrate
n/a
Meas. Tech.
ChEMBL_321105 (CHEMBL882871)
EC50
18700±n/a nM
Citation
 Manetti, D; Di Cesare Mannelli, L; Dei, S; Galeotti, N; Ghelardini, C; Romanelli, MN; Scapecchi, S; Teodori, E; Pacini, A; Bartolini, A; Gualtieri, F Design, synthesis, and preliminary pharmacological evaluation of a set of small molecules that directly activate gi proteins. J Med Chem 48:6491-503 (2005) [PubMed]  Article 
Target
Name:
Guanine nucleotide-binding protein G(i) subunit alpha-3
Synonyms:
GNAI3 | GNAI3_HUMAN | Guanine nucleotide-binding protein G(k), alpha-3 subunit
Type:
PROTEIN
Mol. Mass.:
40527.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_321105
Residue:
354
Sequence:
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKIIHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVLAGSAEEGVMTPELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVKTTGIVETHFTFKDLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEEKIKRSPLTICYPEYTGSNTYEEAAAYIQCQFEDLNRRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKECGLY
  
Inhibitor
Name:
BDBM50174670
Synonyms:
1-Pentadecyl-[4,4']bipiperidinyl; dihydrochloride | CHEMBL535606
Type:
Small organic molecule
Emp. Form.:
C25H50N2
Mol. Mass.:
378.6779
SMILES:
CCCCCCCCCCCCCCCN1CCC(CC1)C1CCNCC1
Structure:
Search PDB for entries with ligand similarity: