Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50176705
Substrate
n/a
Meas. Tech.
ChEMBL_327856 (CHEMBL863986)
Ki
126±n/a nM
Citation
 Starck, JP; Talaga, P; Quéré, L; Collart, P; Christophe, B; Lo Brutto, P; Jadot, S; Chimmanamada, D; Zanda, M; Wagner, A; Mioskowski, C; Massingham, R; Guyaux, M Potent anti-muscarinic activity in a novel series of quinuclidine derivatives. Bioorg Med Chem Lett 16:373-7 (2005) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50176705
Synonyms:
(R)-1,1-bis(4-chlorophenyl)-3-(3-methoxyquinuclidin-3-yl)prop-2-yn-1-ol | CHEMBL199981
Type:
Small organic molecule
Emp. Form.:
C23H23Cl2NO2
Mol. Mass.:
416.34
SMILES:
CO[C@@]1(CN2CCC1CC2)C#CC(O)(c1ccc(Cl)cc1)c1ccc(Cl)cc1 |wU:2.1,wD:2.11,THB:1:2:5.6:9.8,(-1.92,-25.58,;-.43,-25.96,;-.02,-27.46,;.18,-28.83,;1.71,-28.18,;3.08,-28.81,;2.8,-27.42,;1.45,-26.81,;1.52,-25.18,;1.97,-26.28,;-1.51,-27.85,;-3.01,-28.25,;-4.5,-28.64,;-4.89,-27.16,;-5.99,-29.04,;-7.08,-27.95,;-8.57,-28.34,;-8.97,-29.83,;-10.46,-30.23,;-7.88,-30.93,;-6.39,-30.53,;-4.1,-30.13,;-5.19,-31.22,;-4.8,-32.7,;-3.31,-33.11,;-2.91,-34.59,;-2.22,-32.01,;-2.62,-30.53,)|
Structure:
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