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Target
Metabotropic glutamate receptor 7
Ligand
BDBM50007548
Substrate
n/a
Meas. Tech.
ChEMBL_329055 (CHEMBL863304)
EC50
188000±n/a nM
Citation
 Amori, L; Serpi, M; Marinozzi, M; Costantino, G; Diaz, MG; Hermit, MB; Thomsen, C; Pellicciari, R Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues. Bioorg Med Chem Lett 16:196-9 (2005) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 7
Synonyms:
GRM7 protein | metabotropic glutamate 7 | Metabotropic glutamate receptor 7 | GRM7_HUMAN | GRM7 | GPRC1G | MGLUR7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
102262.98
Organism:
Human
Description:
Q14831
Residue:
915
Sequence:
MVQLRKLLRVLTLMKFPCCVLEVLLCALAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
  
Inhibitor
Name:
BDBM50007548
Synonyms:
2-Amino-4-phosphono-butyric acid | 2-amino-4-phosphonobutanoic acid | CHEMBL33567 | L-AP4 | (S)-2-Amino-4-phosphono-butyric acid | 2-amino-4-phosphonobutyric acid | L-1-amino-4-phosphonobutanoic acid | 2-Amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid | 2-Amino-4-phosphono-butyric acid(S-AP4) | L-APB | (S)-2-amino-4-phosphonobutanoic acid | L-(+)-2-amino-4-phosphonobutyric acid
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: