Reaction Details Report a problem with these data
Target
Falcipain 2B
Ligand
BDBM50073850
Substrate
n/a
Meas. Tech.
ChEMBL_356421 (CHEMBL867545)
IC50
5000±n/a nM
Citation
 Micale, N; Kozikowski, AP; Ettari, R; Grasso, S; Zappalà, M; Jeong, JJ; Kumar, A; Hanspal, M; Chishti, AH Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents. J Med Chem 49:3064-7 (2006) [PubMed]  Article 
Target
Name:
Falcipain 2B
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
27119.28
Organism:
Plasmodium falciparum
Description:
ChEMBL_356421
Residue:
241
Sequence:
QINYDAVIKKYKGNENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICTDDDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISIAVSDDFPFYKEGIFDGECGDELNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50073850
Synonyms:
(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid | CHEMBL423112 | MDL-28170 | [(S)-1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | [1-(1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | [1-(1-Formyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester | benzyl (2S)-3-methyl-1-oxo-1-(1-oxo-3-phenylpropan-2-ylamino)butan-2-ylcarbamate | benzyl (S)-3-methyl-1-oxo-1-(1-oxo-3-phenylpropan-2-ylamino)butan-2-ylcarbamate
Type:
Small organic molecule
Emp. Form.:
C22H26N2O4
Mol. Mass.:
382.4528
SMILES:
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccccc1)C=O |r|
Structure:
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