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Target
Orotidine 5'-phosphate decarboxylase
Ligand
BDBM21340
Substrate
n/a
Meas. Tech.
ChEMBL_381850 (CHEMBL869172)
Ki
64±n/a nM
Citation
 Poduch, E; Bello, AM; Tang, S; Fujihashi, M; Pai, EF; Kotra, LP Design of inhibitors of orotidine monophosphate decarboxylase using bioisosteric replacement and determination of inhibition kinetics. J Med Chem 49:4937-45 (2006) [PubMed]  Article 
Target
Name:
Orotidine 5'-phosphate decarboxylase
Synonyms:
Orotidine phosphate decarboxylase | PYRF_YEAST | URA3
Type:
PROTEIN
Mol. Mass.:
29241.18
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_639015
Residue:
267
Sequence:
MSKATYKERAATHPSPVAAKLFNIMHEKQTNLCASLDVRTTKELLELVEALGPKICLLKTHVDILTDFSMEGTVKPLKALSAKYNFLLFEDRKFADIGNTVKLQYSAGVYRIAEWADITNAHGVVGPGIVSGLKQAAEEVTKEPRGLLMLAELSCKGSLATGEYTKGTVDIAKSDKDFVIGFIAQRDMGGRDEGYDWLIMTPGVGLDDKGDALGQQYRTVDDVVSTGSDIIIVGRGLFAKGRDAKVEGERYRKAGWEAYLRRCGQQN
  
Inhibitor
Name:
BDBM21340
Synonyms:
6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4R,5R)-5-(3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazin-2-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C8H12N3O9P
Mol. Mass.:
325.1693
SMILES:
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1ncc(=O)[nH]c1=O |r|
Structure:
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