Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50195595
Substrate
n/a
Meas. Tech.
ChEMBL_414098 (CHEMBL908314)
Ki
30.6±n/a nM
Citation
 Semeraro, T; Lossani, A; Botta, M; Ghiron, C; Alvarez, R; Manetti, F; Mugnaini, C; Valensin, S; Focher, F; Corelli, F Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity. J Med Chem 49:6037-45 (2006) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50195595
Synonyms:
2-amino-1,5-dihydro-7-[[[N-[2-(hydroxy)ethyl]-N-methyl]amino]methyl]-4H-pyrrolo[3,2-d]pyrimidin-4-one diacetate
Type:
Small organic molecule
Emp. Form.:
C10H15N5O2
Mol. Mass.:
237.2584
SMILES:
CN(CCO)Cc1c[nH]c2c1nc(N)[nH]c2=O
Structure:
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