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Target
Prostacyclin receptor
Ligand
BDBM50097792
Substrate
n/a
Meas. Tech.
ChEMBL_424243 (CHEMBL909017)
Ki
>500±n/a nM
Citation
 Belley, M; Chan, CC; Gareau, Y; Gallant, M; Juteau, H; Houde, K; Lachance, N; Labelle, M; Sawyer, N; Tremblay, N; Lamontagne, S; Carrière, MC; Denis, D; Greig, GM; Slipetz, D; Gordon, R; Chauret, N; Li, C; Zamboni, RJ; Metters, KM Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett 16:5639-42 (2006) [PubMed]  Article 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM50097792
Synonyms:
(E)-3-(2-Naphthalen-2-ylmethyl-phenyl)-acrylic acid | 3-(2-(naphthalen-2-ylmethyl)phenyl)acrylic acid | CHEMBL423815
Type:
Small organic molecule
Emp. Form.:
C20H16O2
Mol. Mass.:
288.3398
SMILES:
OC(=O)\C=C\c1ccccc1Cc1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: