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Target
UDP-glucose 4-epimerase
Ligand
BDBM50186231
Substrate
n/a
Meas. Tech.
ChEMBL_424499 (CHEMBL911909)
IC50
14000±n/a nM
Citation
 Urbaniak, MD; Tabudravu, JN; Msaki, A; Matera, KM; Brenk, R; Jaspars, M; Ferguson, MA Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett 16:5744-7 (2006) [PubMed]  Article 
Target
Name:
UDP-glucose 4-epimerase
Synonyms:
GALE | GALE_HUMAN
Type:
PROTEIN
Mol. Mass.:
38282.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_424499
Residue:
348
Sequence:
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
  
Inhibitor
Name:
BDBM50186231
Synonyms:
(2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid | CHEMBL456 | ETHACRYNIC ACID | Edecrin | Etacrinic acid | Ethacrynate | Hydromedin | Methylenebutyrylphenoxyacetic acid | [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid | jm5b01461, Compound 72
Type:
Small organic molecule
Emp. Form.:
C13H12Cl2O4
Mol. Mass.:
303.138
SMILES:
CCC(=C)C(=O)c1ccc(OCC(O)=O)c(Cl)c1Cl
Structure:
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