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Target
Nucleoside triphosphate diphosphohydrolase 3
Ligand
BDBM50195359
Substrate
n/a
Meas. Tech.
ChEMBL_424932 (CHEMBL911344)
Ki
112000±n/a nM
Citation
 Müller, CE; Iqbal, J; Baqi, Y; Zimmermann, H; Röllich, A; Stephan, H Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors. Bioorg Med Chem Lett 16:5943-7 (2006) [PubMed]  Article 
Target
Name:
Nucleoside triphosphate diphosphohydrolase 3
Synonyms:
Ectonucleoside triphosphate diphosphohydrolase 3, isoform CRA_a | Protein Entpd3
Type:
PROTEIN
Mol. Mass.:
59110.31
Organism:
Rattus norvegicus
Description:
ChEMBL_612641
Residue:
529
Sequence:
MFTVMTRQPCEQAGFRALSRTPAIVTLVVLLVSIVVLVTLTLIQIHHPQVLSPGLKYGIVLDAGSSRTTVYVYQWPAEKENNTGVVSQTFRCSVKGSGISSYENNPQDAPKAFEDCMLKVKEQVPKHLHESTRVYLGATAGMRLLRLQNETAAHEVLESIQSYFKSQPFDFRGAQIISGQEEGVYGWITANYIMGNFLEKNLWHMWVHPHGVDTTGALDLGGASTQISFVSEEKMEPNASDTVQVSLYGYTYTLYTHSFQCYGRNEAEKKFLAMLLQSPSTDANISNPCYPHGYSTTFTMGHVFGSLCTEKQRPKSYNPSDTITFTGTGDPQLCREKVASVFDFSACQEQDACSFDGIYQPKVQGPFVAFAGFYYTASALNLSGSFSLTSFNDSSWDFCRHTWSELPSLLPRFDETYARSYCFSAHYIYHLLINGYKFTEATWPQIRFEKEVGNSSIAWSLGYMLSLTNQIPAGSPLIQLPIQPPVFMGVLAFFTAIALLCLAFLFYLCSAFRTKERSENAFDQAVDSD
  
Inhibitor
Name:
BDBM50195359
Synonyms:
ARL-67156 | CHEMBL223145
Type:
Small organic molecule
Emp. Form.:
C15H20Br2N5O12P3
Mol. Mass.:
715.077
SMILES:
CCN(CC)c1ncnc2n(cnc12)[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]1O |r|
Structure:
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