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Target
Translocator protein
Ligand
BDBM50205315
Substrate
n/a
Meas. Tech.
ChEMBL_425937 (CHEMBL906334)
IC50
60.1±n/a nM
Citation
 Zhang, MR; Kumata, K; Maeda, J; Haradahira, T; Noguchi, J; Suhara, T; Halldin, C; Suzuki, K N-(5-Fluoro-2-phenoxyphenyl)-N-(2-[(131)I]iodo-5-me thoxybenzyl)acetamide: a potent iodinated radioligand for the peripheral-type benzodiazepine receptor in brain. J Med Chem 50:848-55 (2007) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50205315
Synonyms:
CHEMBL220642 | N-(2,5-dimethoxybenzyl)-N-(5-iodo-2-phenoxyphenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C23H22INO4
Mol. Mass.:
503.3296
SMILES:
COc1ccc(OC)c(CN(C(C)=O)c2cc(I)ccc2Oc2ccccc2)c1
Structure:
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