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Target
Cysteine protease falcipain-3 [5-492]
Ligand
BDBM50157739
Substrate
n/a
Meas. Tech.
ChEMBL_430127 (CHEMBL919605)
IC50
62200±n/a nM
Citation
 Desai, PV; Patny, A; Sabnis, Y; Tekwani, B; Gut, J; Rosenthal, P; Srivastava, A; Avery, M Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database. J Med Chem 47:6609-15 (2004) [PubMed]  Article 
Target
Name:
Cysteine protease falcipain-3 [5-492]
Synonyms:
Cysteine protease falcipain-3 | Q9NAW4_PLAFA
Type:
PROTEIN
Mol. Mass.:
56106.86
Organism:
Plasmodium falciparum
Description:
ChEMBL_430127
Residue:
488
Sequence:
MEYSPNEVIKQEREVFVGKEKSGSKFKRKRSIFIVLTVSICFMFALMLFYFTRNENNKTLFTNSLSNNINDDYIINSLLKSESGKKFIVSKLEELISSYDKEKKMRTTGAEENNMNMNGIDDKDNKSVSFVNKKNGNLKVNNNNQVSYSNLFDTKFLMDNLETVNLFYIFLKENNKKYETSEEMQKRFIIFSENYRKIELHNKKTNSLYKRGMNKFGDLSPEEFRSKYLNLKTHGPFKTLSPPVSYEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVESQYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPETCNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPNHAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGTEAYVPLLE
  
Inhibitor
Name:
BDBM50157739
Synonyms:
CHEMBL426564 | N'-(2-oxo-1-(2-oxo-2-(phenylamino)ethyl)indolin-3-ylidene)isonicotinohydrazide
Type:
Small organic molecule
Emp. Form.:
C22H17N5O3
Mol. Mass.:
399.4021
SMILES:
O=C(CN1C(=O)C(=NNC(=O)c2ccncc2)c2ccccc12)Nc1ccccc1 |w:7.7|
Structure:
Search PDB for entries with ligand similarity: