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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50142839
Substrate
n/a
Meas. Tech.
ChEMBL_436641 (CHEMBL904951)
Ki
75±n/a nM
Citation
 Kim, DI; Deutsch, HM; Ye, X; Schweri, MM Synthesis and pharmacology of site-specific cocaine abuse treatment agents: restricted rotation analogues of methylphenidate. J Med Chem 50:2718-31 (2007) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50142839
Synonyms:
(R)-2-((R)-Methoxycarbonyl-phenyl-methyl)-piperidinium; chloride | (R)-methyl 2-phenyl-2-((R)-piperidin-2-yl)acetate hydrochloride | CHEMBL904 | DEXMETHYLPHENIDATE HYDROCHLORIDE | Focalin | Focalin xr
Type:
Small organic molecule
Emp. Form.:
C14H20NO2
Mol. Mass.:
234.3136
SMILES:
COC(=O)[C@@H]([C@H]1CCCC[NH2+]1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: