Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 3
Ligand
BDBM50211135
Substrate
n/a
Meas. Tech.
ChEMBL_438654 (CHEMBL888985)
IC50
2300±n/a nM
Citation
Johnson, M; Li, AR; Liu, J; Fu, Z; Zhu, L; Miao, S; Wang, X; Xu, Q; Huang, A; Marcus, A; Xu, F; Ebsworth, K; Sablan, E; Danao, J; Kumer, J; Dairaghi, D; Lawrence, C; Sullivan, T; Tonn, G; Schall, T; Collins, T; Medina, J Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3. Bioorg Med Chem Lett 17:3339-43 (2007) [PubMed] Article
More Info.:
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40665.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
Inhibitor
Name:
BDBM50211135
Synonyms:
2-biphenyl-4-yl-N-(2-ethoxy-ethyl)-N-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-acetamide | CHEMBL231487
Type:
Small organic molecule
Emp. Form.:
C35H35N3O4
Mol. Mass.:
561.6701
SMILES:
CCOCCN(Cc1nc2ccccc2c(=O)n1-c1ccc(OCC)cc1)C(=O)Cc1ccc(cc1)-c1ccccc1