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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50217445
Substrate
n/a
Meas. Tech.
ChEMBL_444681 (CHEMBL894930)
IC50
4±n/a nM
Citation
 Hwang, SH; Tsai, HJ; Liu, JY; Morisseau, C; Hammock, BD Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem 50:3825-40 (2007) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic
Type:
Enzyme
Mol. Mass.:
62613.07
Organism:
Homo sapiens (Human)
Description:
P34913
Residue:
555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
  
Inhibitor
Name:
BDBM50217445
Synonyms:
CHEMBL397669 | cis-1-adamantan-1-yl-3-(4-methoxycyclohexyl)urea
Type:
Small organic molecule
Emp. Form.:
C24H40N2O2
Mol. Mass.:
388.5866
SMILES:
O=C(N[C@H]1CC[C@@H](CC1)OCC1CCCCC1)NC12CC3CC(CC(C3)C1)C2 |wU:6.9,wD:3.2,TLB:17:18:21.20.25:23,THB:19:20:23:27.18.26,19:18:21.20.25:23,26:18:21:25.24.23,26:24:21:27.19.18,17:18:21:25.24.23,(-5.73,-20.09,;-4.9,-21.4,;-3.36,-21.34,;-2.65,-19.97,;-1.1,-19.92,;-.39,-18.56,;-1.2,-17.26,;-2.74,-17.31,;-3.47,-18.68,;-.48,-15.9,;1.06,-15.84,;1.78,-14.48,;3.32,-14.43,;4.04,-13.07,;3.23,-11.76,;1.69,-11.82,;.96,-13.18,;-5.62,-22.76,;-7.16,-22.82,;-8.17,-24.1,;-9.58,-23.54,;-11.08,-23.96,;-9.88,-22.68,;-9.89,-21.19,;-8.54,-20.72,;-9.59,-21.95,;-7.15,-21.29,;-8.56,-23.17,)|
Structure:
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