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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50217450
Substrate
n/a
Meas. Tech.
ChEMBL_444681 (CHEMBL894930)
IC50
3.4±n/a nM
Citation
 Hwang, SH; Tsai, HJ; Liu, JY; Morisseau, C; Hammock, BD Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem 50:3825-40 (2007) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic
Type:
Enzyme
Mol. Mass.:
62613.07
Organism:
Homo sapiens (Human)
Description:
P34913
Residue:
555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
  
Inhibitor
Name:
BDBM50217450
Synonyms:
CHEMBL397426 | cis-1-adamantan-1-yl-3-[4-(2-methylbenzyloxy)cyclohexyl]-urea
Type:
Small organic molecule
Emp. Form.:
C25H36N2O2
Mol. Mass.:
396.5655
SMILES:
Cc1ccccc1CO[C@@H]1CC[C@@H](CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2 |wU:12.16,9.9,TLB:18:19:22.21.26:24,THB:20:21:24:28.19.27,20:19:22.21.26:24,27:19:22:26.25.24,27:25:22:28.20.19,18:19:22:26.25.24,(5.6,-48.13,;4.79,-46.82,;5.51,-45.47,;4.7,-44.16,;3.16,-44.21,;2.43,-45.57,;3.25,-46.87,;2.53,-48.23,;.99,-48.29,;.27,-49.65,;-1.27,-49.7,;-2,-51.07,;-1.18,-52.36,;.37,-52.31,;1.09,-50.95,;-1.89,-53.73,;-3.43,-53.79,;-4.25,-52.49,;-4.15,-55.15,;-5.69,-55.21,;-6.7,-56.49,;-8.11,-55.93,;-9.61,-56.35,;-8.41,-55.07,;-8.42,-53.58,;-7.07,-53.11,;-8.11,-54.34,;-5.67,-53.69,;-7.09,-55.56,)|
Structure:
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