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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50217456
Substrate
n/a
Meas. Tech.
ChEMBL_444681 (CHEMBL894930)
IC50
1.3±n/a nM
Citation
 Hwang, SH; Tsai, HJ; Liu, JY; Morisseau, C; Hammock, BD Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem 50:3825-40 (2007) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic
Type:
Enzyme
Mol. Mass.:
62613.07
Organism:
Homo sapiens (Human)
Description:
P34913
Residue:
555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
  
Inhibitor
Name:
BDBM50217456
Synonyms:
CHEMBL243337 | cis-1-adamantan-1-yl-3-[4-(4-bromophenoxy)cyclohexyl]urea
Type:
Small organic molecule
Emp. Form.:
C23H31BrN2O2
Mol. Mass.:
447.408
SMILES:
Brc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 |wU:9.12,6.5,TLB:15:16:19.18.23:21,THB:17:18:21:25.16.24,17:16:19.18.23:21,24:16:19:23.22.21,24:22:19:25.17.16,15:16:19:23.22.21,(34.37,3.49,;32.83,3.43,;32.1,2.07,;30.57,2.01,;29.75,3.32,;28.21,3.26,;27.49,1.9,;25.95,1.84,;25.23,.48,;26.04,-.82,;27.59,-.76,;28.31,.59,;25.33,-2.18,;23.79,-2.24,;22.97,-.94,;23.07,-3.6,;21.53,-3.67,;20.52,-4.94,;19.11,-4.38,;17.61,-4.8,;18.81,-3.52,;18.8,-2.04,;20.15,-1.56,;19.11,-2.79,;21.55,-2.14,;20.13,-4.01,;30.47,4.68,;32,4.74,)|
Structure:
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