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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50217461
Substrate
n/a
Meas. Tech.
ChEMBL_444681 (CHEMBL894930)
IC50
0.9±n/a nM
Citation
 Hwang, SH; Tsai, HJ; Liu, JY; Morisseau, C; Hammock, BD Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem 50:3825-40 (2007) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic
Type:
Enzyme
Mol. Mass.:
62613.07
Organism:
Homo sapiens (Human)
Description:
P34913
Residue:
555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
  
Inhibitor
Name:
BDBM50217461
Synonyms:
CHEMBL242898 | cis-1-adamantan-1-yl-3-(4-benzyloxycyclohexyl)urea
Type:
Small organic molecule
Emp. Form.:
C24H34N2O2
Mol. Mass.:
382.539
SMILES:
O=C(N[C@H]1CC[C@H](CC1)OCc1ccccc1)NC12CC3CC(CC(C3)C1)C2 |wD:3.2,6.9,TLB:17:18:21.20.25:23,THB:19:20:23:27.18.26,19:18:21.20.25:23,26:18:21:25.24.23,26:24:21:27.19.18,17:18:21:25.24.23,(-5.79,-36.39,;-4.96,-37.7,;-3.42,-37.63,;-2.71,-36.27,;-1.16,-36.22,;-.45,-34.86,;-1.26,-33.55,;-2.8,-33.61,;-3.53,-34.98,;-.54,-32.19,;1,-32.14,;1.72,-30.78,;3.26,-30.73,;3.98,-29.37,;3.17,-28.06,;1.63,-28.12,;.9,-29.48,;-5.68,-39.06,;-7.22,-39.12,;-8.23,-40.4,;-9.64,-39.84,;-11.14,-40.25,;-9.94,-38.98,;-9.95,-37.49,;-8.6,-37.02,;-9.65,-38.25,;-7.21,-37.59,;-8.62,-39.47,)|
Structure:
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