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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50217465
Substrate
n/a
Meas. Tech.
ChEMBL_444681 (CHEMBL894930)
IC50
4±n/a nM
Citation
 Hwang, SH; Tsai, HJ; Liu, JY; Morisseau, C; Hammock, BD Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem 50:3825-40 (2007) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic
Type:
Enzyme
Mol. Mass.:
62613.07
Organism:
Homo sapiens (Human)
Description:
P34913
Residue:
555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
  
Inhibitor
Name:
BDBM50217465
Synonyms:
CHEMBL242470 | trans-1-adamantan-1-yl-3-(4-cyclohexylmethoxycyclohexyl)-urea
Type:
Small organic molecule
Emp. Form.:
C18H30N2O2
Mol. Mass.:
306.443
SMILES:
CO[C@@H]1CC[C@@H](CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2 |wD:5.8,2.1,TLB:11:12:15.14.19:17,THB:13:14:17:21.12.20,13:12:15.14.19:17,20:12:15:19.18.17,20:18:15:21.13.12,11:12:15:19.18.17,(32.43,-1.35,;30.89,-1.4,;30.17,-2.76,;30.99,-4.07,;30.27,-5.42,;28.73,-5.48,;27.91,-4.18,;28.63,-2.82,;28.01,-6.84,;26.47,-6.9,;25.65,-5.6,;25.75,-8.27,;24.22,-8.33,;23.2,-9.6,;21.79,-9.04,;20.3,-9.46,;21.49,-8.19,;21.48,-6.7,;22.83,-6.22,;21.79,-7.46,;24.23,-6.8,;22.82,-8.67,)|
Structure:
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