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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50217466
Substrate
n/a
Meas. Tech.
ChEMBL_444681 (CHEMBL894930)
IC50
2.1±n/a nM
Citation
 Hwang, SH; Tsai, HJ; Liu, JY; Morisseau, C; Hammock, BD Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem 50:3825-40 (2007) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic
Type:
Enzyme
Mol. Mass.:
62613.07
Organism:
Homo sapiens (Human)
Description:
P34913
Residue:
555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
  
Inhibitor
Name:
BDBM50217466
Synonyms:
CHEMBL242460 | cis-1-adamantan-1-yl-3-[4-(4-bromobenzyloxy)cyclohexyl]-urea
Type:
Small organic molecule
Emp. Form.:
C24H33BrN2O2
Mol. Mass.:
461.435
SMILES:
Brc1ccc(CO[C@@H]2CC[C@@H](CC2)NC(=O)NC23CC4CC(CC(C4)C2)C3)cc1 |wU:10.13,7.6,TLB:16:17:20.19.24:22,THB:18:19:22:26.17.25,18:17:20.19.24:22,25:17:20:24.23.22,25:23:20:26.18.17,16:17:20:24.23.22,(26.78,-26.25,;26.06,-27.61,;26.87,-28.92,;26.15,-30.28,;24.61,-30.33,;23.89,-31.69,;22.35,-31.74,;21.63,-33.1,;20.09,-33.16,;19.36,-34.53,;20.18,-35.82,;21.73,-35.77,;22.44,-34.41,;19.46,-37.18,;17.93,-37.25,;17.1,-35.94,;17.21,-38.61,;15.67,-38.67,;14.66,-39.95,;13.25,-39.39,;11.75,-39.8,;12.95,-38.53,;12.94,-37.04,;14.28,-36.57,;13.24,-37.8,;15.68,-37.14,;14.27,-39.02,;23.79,-29.03,;24.52,-27.66,)|
Structure:
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