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Target
Bifunctional epoxide hydrolase 2
Ligand
BDBM50217471
Substrate
n/a
Meas. Tech.
ChEMBL_444681 (CHEMBL894930)
IC50
9.1±n/a nM
Citation
 Hwang, SH; Tsai, HJ; Liu, JY; Morisseau, C; Hammock, BD Orally bioavailable potent soluble epoxide hydrolase inhibitors. J Med Chem 50:3825-40 (2007) [PubMed]  Article 
Target
Name:
Bifunctional epoxide hydrolase 2
Synonyms:
Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic
Type:
Enzyme
Mol. Mass.:
62613.07
Organism:
Homo sapiens (Human)
Description:
P34913
Residue:
555
Sequence:
MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITLSQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTAILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEVVFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHGYVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESSAPPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMHKVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSLGRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIKWLDSDARNPPVVSKM
  
Inhibitor
Name:
BDBM50217471
Synonyms:
CHEMBL243302 | cis-2-adamantan-1-yl-N-[4-(4-fluorophenoxy)cyclohexyl]acetamide
Type:
Small organic molecule
Emp. Form.:
C24H32FNO2
Mol. Mass.:
385.5148
SMILES:
Fc1ccc(O[C@@H]2CC[C@@H](CC2)NC(=O)CC23CC4CC(CC(C4)C2)C3)cc1 |wD:9.12,6.5,TLB:15:16:19.18.23:21,THB:17:18:21:25.16.24,17:16:19.18.23:21,24:16:19:23.22.21,24:22:19:25.17.16,15:16:19:23.22.21,(36.25,-9.09,;34.71,-9.15,;33.99,-10.51,;32.45,-10.57,;31.63,-9.26,;30.09,-9.32,;29.38,-10.68,;30.2,-11.99,;29.48,-13.33,;27.93,-13.39,;27.11,-12.1,;27.84,-10.73,;27.22,-14.75,;25.68,-14.81,;24.85,-13.52,;24.96,-16.18,;23.42,-16.24,;22.4,-17.52,;21,-16.96,;19.5,-17.37,;20.69,-16.1,;20.69,-14.61,;22.03,-14.14,;21,-15.37,;23.43,-14.71,;22.02,-16.59,;32.35,-7.9,;33.89,-7.84,)|
Structure:
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