Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50219754
Substrate
n/a
Meas. Tech.
ChEMBL_445893 (CHEMBL896183)
Ki
3450±n/a nM
Citation
 Ferorelli, S; Abate, C; Colabufo, NA; Niso, M; Inglese, C; Berardi, F; Perrone, R Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies. J Med Chem 50:4648-55 (2007) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50219754
Synonyms:
1-cyclohexyl-4-[3-(9H-carbazol-9-yl)propyl]piperazine hydrochloride | CHEMBL536305
Type:
Small organic molecule
Emp. Form.:
C25H33N3
Mol. Mass.:
375.5496
SMILES:
C(CN1CCN(CC1)C1CCCCC1)Cn1c2ccccc2c2ccccc12
Structure:
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