Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50145022
Substrate
n/a
Meas. Tech.
ChEMBL_445893 (CHEMBL896183)
Ki
1.57±n/a nM
Citation
 Ferorelli, S; Abate, C; Colabufo, NA; Niso, M; Inglese, C; Berardi, F; Perrone, R Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies. J Med Chem 50:4648-55 (2007) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50145022
Synonyms:
1-Cyclohexyl-4-[3-(5-methoxy-naphthalen-1-yl)-propyl]-piperazine | 1-cyclohexyl-4-(3-(5-methoxynaphthalen-1-yl)propyl)piperazine | CHEMBL535856 | CHEMBL75286 | PB-183
Type:
Small organic molecule
Emp. Form.:
C24H34N2O
Mol. Mass.:
366.5396
SMILES:
COc1cccc2c(CCCN3CCN(CC3)C3CCCCC3)cccc12
Structure:
Search PDB for entries with ligand similarity: